Endocrine Abstracts

Introduction: Pituitary adenomas account for 10–25% of all intracranial tumours. Although rarely malignant, they are associated with high morbidity due to severe endocrine effects and difficult surgical access. Alternative splicing (AS) consists in selective removal of non-coding regions from pre-mRNA and joining of coding regions to produce mRNA variants that may be further translated. AS is regulated by splicing factors and is often disturbed in cancer. AS of growth hor...